Globally, one-third of women have endured sexual or physical violence during their lives. The number of excess COVID-19 fatalities has exceeded 16 million, and cancer accounts for one in six global deaths. Emerging challenges will arise due to the climate crisis and the erosion of democratic principles. Tackling these challenges demands cost-effective, scalable and systematic solutions. This panel will delve into hard evidence and pioneering collaborations within the entertainment and international development sectors that systematically expand media and social influencer interventions on a global scale.